When managing your dog’s allergies, finding the right treatment is key to improving their quality of life. For many pet owners, Apoquel is a go-to medication for relieving itching and inflammation caused by allergies. However, due to its side effects, cost, and the fact that it doesn’t work for every dog, pet owners are increasingly seeking alternatives. Based on real-world experiences shared in online communities, here are some of the top alternatives to Apoquel for treating dog allergies.1Cosgrove, S. B., et al. (2013). Long‐term compassionate use of oclacitinib in dogs with atopic and allergic skin disease: safety, efficacy, and quality of life. Veterinary Dermatology, 24(6), 584-e140.
How Apoquel Works?
Apoquel is made of oclacitinib, its active ingredient, which works by inhibiting Janus kinases (JAK1 and JAK3)—enzymes involved in the immune response that causes itching and inflammation in dogs. By blocking these enzymes, oclacitinib reduces allergic reactions without the broad immune suppression of steroids.
The tablet also contains inactive ingredients such as microcrystalline cellulose (a filler), lactose monohydrate (a stabilizer), croscarmellose sodium (helps break down the tablet), and magnesium stearate (a lubricant for manufacturing).
Why Look for Alternatives to Apoquel?
Side Effects
While Apoquel is generally well-tolerated, some dogs experience side effects. A study found that about 5% of dogs on Apoquel experienced adverse effects such as vomiting, diarrhea, and increased susceptibility to infections2Cosgrove, S. B., et al. (2013). Long‐term compassionate use of oclacitinib in dogs with atopic and allergic skin disease: safety, efficacy, and quality of life. Veterinary Dermatology, 24(6), 584-e140. Some pet owners have expressed concerns about these potential side effects, leading them to explore homeopathic treatments as safer alternatives. Although most dogs respond well to Apoquel, the risk of side effects remains a significant consideration for some.34
Ineffectiveness
For certain dogs, Apoquel may not provide sufficient relief. A clinical trial revealed that about 30% of dogs did not respond adequately to Apoquel treatment56 This lack of efficacy is a driving factor behind many pet owners seeking alternative options, ranging from other prescription medications to natural remedies and lifestyle adjustments.
These factors contribute to the growing interest in Apoquel alternatives, from other prescription options to more natural remedies that may better suit individual dogs’ needs.
Prescription Alternatives
If Apoquel isn’t right for your dog, there are several prescription-based alternatives that may work better:
Steroids
Steroids, such as prednisone, can provide short-term relief for allergic reactions. Vet prescribed low dose of steroids, could help control dog’s symptoms without significant side effects. However, steroids are generally not recommended for long-term use due to potential complications.
Hydroxyzine
Hydroxyzine, an antihistamine, could be an effective prescription alternative. It may be a good option for dogs with milder symptoms and is often less expensive than Apoquel. Always consult your vet to determine the right dosage and monitor for any side effects.
Natural and Holistic Alternatives
Many dog owners are turning to natural remedies, which can be effective in reducing allergy symptoms without the risks of side effects.
Probiotics and Colostrum
Some pet owners suggests addressing the root cause of allergies by improving gut health through probiotics and colostrum. These supplements are believed to support the immune system and reduce inflammation, leading to fewer allergy flare-ups.
Quercetin
Quercetin is a natural antihistamine that works similarly to Benadryl. It’s known as “nature’s Benadryl” and is available at many stores like Walmart. This option can help with seasonal allergies or mild skin irritation.
Oregano Oil and Colloidal Silver
Oregano oil has antimicrobial and anti-inflammatory properties, making it a potential treatment for infections associated with skin allergies. However, it’s potent and must be used with caution.
Colloidal Silver: While some anecdotal evidence supports colloidal silver, no major veterinary studies have conclusively proven its efficacy for allergies in dogs. However, it’s often recommended for its antimicrobial properties.
Susan Rockwell recommends making colloidal silver at home to treat allergy-related infections. This natural remedy is believed to have anti-inflammatory and antimicrobial properties, though it should be used carefully and with vet consultation.
Golden Paste
Golden Paste which is made from turmeric, has anti-inflammatory benefits. This can be given orally to help reduce itching and inflammation.
Raw Diet and Novel Protein Diets
Dietary changes can also play a role in reducing allergy symptoms. Pet owners suggested switching to a raw diet or eliminating common allergens like chicken from the dog’s food. Dogs with food allergies may benefit from a novel protein diet, where they are given proteins they haven’t been exposed to before, such as duck or venison.
The Role of Gut Health in Managing Allergies
Commercial Products
In addition to natural remedies, some pet owners have found relief through commercial products specifically designed for dog allergies.
Nutripaw Anti Allergy
Harmony by Four Leaf Rover
Additional Strategies
Pet owners often emphasize the importance of environmental management and regular grooming to reduce allergens.
Medicated Shampoos
Regular baths are critical for dogs with environmental allergies. Many users recommend Malaseb or Pyohex shampoos, which are medicated and help cleanse allergens from the dog’s skin and coat. Using hypoallergenic wipes after walks can also prevent allergens from accumulating on the dog’s skin.
Environmental Management
Environmental allergens like pollen can be a significant trigger. Weekly baths and conditioning with products like Dermacre Barazone mousse help soothe the skin. Wiping down the dog’s coat daily and using a medicated shampoo regularly is also commonly suggested by the pet owners.
Conclusion
Apoquel and Cytopoint work for some dogs, they are not the only options available. From prescription alternatives like Hydroxyzine and steroids to natural remedies like probiotics, quercetin, and colloidal silver, pet owners have found a variety of solutions. Products like Nutripaw Anti Allergy and Harmony by Four Leaf Rover have also helped many dogs find relief from chronic allergies.
- 1Cosgrove, S. B., et al. (2013). Long‐term compassionate use of oclacitinib in dogs with atopic and allergic skin disease: safety, efficacy, and quality of life. Veterinary Dermatology, 24(6), 584-e140.
- 2Cosgrove, S. B., et al. (2013). Long‐term compassionate use of oclacitinib in dogs with atopic and allergic skin disease: safety, efficacy, and quality of life. Veterinary Dermatology, 24(6), 584-e140.
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